Article
[Population genetic analysis of the association between the BRCA1 and P53 gene polymorphisms and the risk of sporadic breast cancer].
Genetika - 1 Aug 2005
Tarasov V A, Aslanian M M, Tsyrendorzhieva E S, Gar'kavtseva R F, Liubchenko L N, Altukhov Iu P, Mel'nik V A
Abstract excerpt
Polymorphism of two tumor-suppressor genes, BRCA1 and P53, was examined. DNA was extracted from blood leukocytes of the women affected with breast cancer (N = 151) and of the women with no clinical symptoms of tumor diseases (N = 191). Typing of the polymorphic variants was performed using PCR-RFLP method. It was demonstrated that the genetic structure of the patient group (taking into consideration BRCA1 and P53...
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