[Population genetic analysis of the association between the BRCA1 and P53 gene polymorphisms and the risk of sporadic breast cancer].

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Article

[Population genetic analysis of the association between the BRCA1 and P53 gene polymorphisms and the risk of sporadic breast cancer].

Genetika - 1 Aug 2005

Tarasov V A, Aslanian M M, Tsyrendorzhieva E S, Gar'kavtseva R F, Liubchenko L N, Altukhov Iu P, Mel'nik V A

Abstract excerpt

Polymorphism of two tumor-suppressor genes, BRCA1 and P53, was examined. DNA was extracted from blood leukocytes of the women affected with breast cancer (N = 151) and of the women with no clinical symptoms of tumor diseases (N = 191). Typing of the polymorphic variants was performed using PCR-RFLP method. It was demonstrated that the genetic structure of the patient group (taking into consideration BRCA1 and P53...

Topics

Alleles
BRCA1 Protein
Breast Neoplasms
Female
Genetic Predisposition to Disease
Genotype
Humans
Polymorphism, Restriction Fragment Length
Risk Factors
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 16161633

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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