Article
[Search for frequently encountered mutations in genes predisposing to breast cancer].
Genetika - 1 Dec 2001
Mandel'shtam M Iu, Golubkov V I, Lamber E P, Shapiro I M, Brezhneva T V, Semiglazov V F, Lipovetskiĭ B M, Hanson K P, Gaĭtskhoki V S
Abstract excerpt
DNA of oncological patients, including Ashkenazi Jews and Slavs, living in St. Petersburg was collected, and the resultant collection was screened for three common mutations of genes BRCA1 and BRCA2 by means of heteroduplex analysis. The mutation 5382insC in exon 20 of the BRCA1 gene was found in four unrelated patients, including three Slavs and one Ashkenazi Jew, with a positive family history of breast cancer....
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