Article
Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1.
International journal of cancer - 1 Mar 2006
Kato Hidenori, Inoue Takafumi, Asanoma Kazuo, Nishimura Chie, Matsuda Takao, Wake Norio
Abstract excerpt
Previous observations indicate that transfer of human chromosome (chr.) 1 induces senescence of endometrial cancer cells. To identify the gene(s) responsible for the senescence, we first analyzed the structural integrity of the introduced chr. 1 in immortal revertant from chr.1-transferred HHUA cells. The data demonstrated a correlation between nonrandom deletions within the 1q31-qter region and reversion to...
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