Article
Maternal HLA class II compatibility in men with systemic lupus erythematosus.
Arthritis and rheumatism - 1 Sept 2005
Stevens Anne M, Tsao Betty P, Hahn Bevra H, Guthrie Katherine, Lambert Nathalie C, Porter Allison J, Tylee Tracy S, Nelson J Lee
Abstract excerpt
OBJECTIVE: Maternal-fetal cell transfer during pregnancy can lead to long-lasting microchimerism, which raises the question of whether microchimerism sometimes contributes to autoimmune disease later in life. In an experimental model, transfusion of parental lymphocytes homozygous for major histocompatibility complex alleles results in systemic lupus erythematosus (SLE). We identified male patients with SLE and...
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