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Article

Evolution of human-chimpanzee differences in malaria susceptibility: relationship to human genetic loss of N-glycolylneuraminic acid.

Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2005

Martin Maria J, Rayner Julian C, Gagneux Pascal, Barnwell John W, Varki Ajit

Abstract excerpt

Chimpanzees are the closest evolutionary cousins of humans, sharing >99% identity in most protein sequences. Plasmodium falciparum is the major worldwide cause of malaria mortality. Plasmodium reichenowi, a morphologically identical and genetically very similar parasite, infects chimpanzees but not humans. Conversely, experimental P. falciparum infection causes brief moderate parasitization and no severe...

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Identifiers

PMID: 16126901
DOI: 10.1073/pnas.0503819102
PMCID: PMC1200275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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