Acute myeloid leukaemia with <i>FLT3</i> gene mutations of both internal tandem duplication and point mutation type

Abstract excerpt

FLT3 gene mutations, either internal tandem duplication or point mutation type, are common in acute myeloid leukaemia (AML). We describe 21 AML cases with both types of gene mutations, so-called dual mutations, representing approximately 1% of all cases. Most newly diagnosed AML with FLT3 dual mutations had monocytic differentiation and a normal karyotype. Over the disease course, changes in FLT3 mutation status...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acute Myeloid Leukemia Research
• Share to Protein Degradation and Inhibitors
• Share to Retinoids in leukemia and cellular processes