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Differentiated Alzheimer's Disease Transmitochondrial Cybrid Cell Lines Exhibit Reduced Organelle Movement

22 Aug 2005

Abstract excerpt

The axonal transport and function of organelles like mitochondria and lysosomes may be impaired and play an important role in the pathogenesis of Alzheimer's disease (AD). Unique cybrid cell lines that model AD pathology were created by fusing platelets containing mitochondria from age-matched AD and control volunteers with mitochondrial DNA-free SH-SY5Y human neuroblastoma cells. These cybrid lines were...

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PMID: 16115014
DOI: 10.1089/ars.2005.7.1101

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