Article
Sequence variation and immunologic cross-reactivity among Babesia bovis merozoite surface antigen 1 proteins from vaccine strains and vaccine breakthrough isolates.
Infection and immunity - 1 Sept 2005
Leroith Tanya, Brayton Kelly A, Molloy John B, Bock Russell E, Hines Stephen A, Lew Ala E, McElwain Terry F
Abstract excerpt
The Babesia bovis merozoite surface antigen 1 (MSA-1) is an immunodominant membrane glycoprotein that is the target of invasion-blocking antibodies. While antigenic variation has been demonstrated in MSA-1 among strains from distinct geographical areas, the extent of sequence variation within a region where it is endemic and the effect of variation on immunologic cross-reactivity have not been assessed. In this...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Protozoan
- Babesia bovis
- Babesiosis
- Cattle
- Cattle Diseases
- Cross Reactions
- Genetic Variation
- Male
- Merozoite Surface Protein 1
- Molecular Sequence Data
- Protozoan Vaccines