Article
VAMP5 and VAMP8 are most likely not involved in primary open-angle glaucoma.
Molecular vision - 4 Aug 2005
Brinkman Joep F F, Ottenheim Cecile P E, de Jong Leo A M S, Zegers Richard H C, de Smet Marc D, de Jong Paulus T V M, Bergen Arthur A B
Abstract excerpt
PURPOSE: To select and characterize novel POAG disease genes. On the basis of genetic position (GLC1B), expression in the optic nerve, and biochemical function (targeted membrane transport processes), we selected the human VAMP5 and VAMP8 (encoding vesicle-associated membrane proteins 5 and 8) as potential candidate disease genes for POAG. We subsequently analyzed whether or not sequence changes in VAMP5 or VAMP8...
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