Article
An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.
Cancer research - 15 Aug 2005
Kobayashi Susumu, Ji Hongbin, Yuza Yuki, Meyerson Matthew, Wong Kwok-Kin, Tenen Daniel G, Halmos Balázs
Abstract excerpt
Mutations of the epidermal growth factor receptor (EGFR) gene have been identified in non-small cell lung cancer specimens from patients responding to anilinoquinazoline EGFR inhibitors. However, clinical resistance to EGFR inhibitor therapy is commonly observed. Previously, we showed that such r...
Topics
- Animals
- Antineoplastic Agents
- Apoptosis
- Cell Growth Processes
- Cell Line, Tumor
- DNA-Binding Proteins
- Drug Interactions
- ErbB Receptors
- Gefitinib
- Genes, erbB-1
- Interleukin-3
- Mice
- Milk Proteins
- Mutation
- Phosphorylation