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Article

Evidence for ineffective erythropoiesis in severe sickle cell disease

10 Aug 2005

Abstract excerpt

Peripheral destruction of sickled erythrocytes is a cardinal feature of sickle cell disease (SCD). Less well established is the potential contribution of ineffective erythropoiesis to the pathophysiology of this hemoglobinopathy. Since patients with SCD frequently develop mixed hematopoietic chimerism after allogeneic nonmyeloablative stem cell transplantation, we used this opportunity to directly compare the...

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PMID: 16091448
DOI: 10.1182/blood-2005-04-1376

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