Article
The mutant axolotl Short toes exhibits impaired limb regeneration and abnormal basement membrane formation.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1992
Del Rio-Tsonis K, Washabaugh C H, Tsonis P A
Abstract excerpt
The mutant axolotl Short toes develops with abnormal kidneys, Mullerian ducts, and limbs and provides one of the few experimental systems for developmental studies in amphibia. The present paper describes another deviation from this animal's normal physiology, which is very characteristic of the wild type: amputated limbs of Short toes fail to regenerate. A blastema is formed but differentiation does not occur....
Topics
- Ambystoma
- Amputation, Surgical
- Animals
- Basement Membrane
- DNA
- Extremities
- Fluorescent Antibody Technique
- Humans
- Kidney
- Laminin
- Mutation