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Coculture of THP‐1 Human Mononuclear Cells with<i>Candida albicans</i>Results in Pronounced Changes in Host Gene Expression

5 Aug 2005

Abstract excerpt

BACKGROUND: The host's first line of defense against bloodstream infection with Candida albicans involves the recognition and clearance of the fungus by neutrophils and monocytes/macrophages. The purpose of the present study was to examine changes in the monocytic cell gene-expression profile in response to C. albicans stimulation. METHODS: RNA was isolated from THP-1 cells 3 h after coculture with live C....

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Share to Antifungal resistance and susceptibility
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PMID: 16088841
DOI: 10.1086/432487

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