Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans.

doi:10.1038/ncomms2343

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Article

Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans.

Nature communications - 1 Jan 2013

Smeekens Sanne P, Ng Aylwin, Kumar Vinod, Johnson Melissa D, Plantinga Theo S, van Diemen Cleo, Arts Peer, Verwiel Eugène T P, Gresnigt Mark S, Fransen Karin, van Sommeren Suzanne, Oosting Marije, Cheng Shih-Chin, Joosten Leo A B, Hoischen Alexander, Kullberg Bart-Jan, Scott William K, Perfect John R, van der Meer Jos W M, Wijmenga Cisca, Netea Mihai G, Xavier Ramnik J

Abstract excerpt

Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. Here by integrating transcriptional analysis and functional genomics, we identified Candida-specific host defence mechanisms in humans. Candida induced significant expression of genes from the type I interferon pathway in human peripheral blood mononuclear...

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PMID: 23299892
DOI: 10.1038/ncomms2343
PMCID: PMC3625375

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