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Article

Antifungals influence the immune-related transcriptomic landscape of human monocytes after Aspergillus fumigatus infection

17 Mar 2022

Abstract excerpt

The heterogeneity of clinical responses to antifungals in aspergillosis is partially understood. We hypothesized that besides direct antifungal effects, these discrepancies may be related to different immunomodulatory profiles. Human THP-1 monocytes were coincubated in vitro with Aspergillus fumigatus and variable concentrations of voriconazole (0.5, 1 and 2 mg/l), caspofungin (1 and 2 mg/l), amphotericin B...

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PMID: 35301416
DOI: 10.1038/s41598-022-08738-4

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