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Inhibitor κB-like proteins from a polydnavirus inhibit NF-κB activation and suppress the insect immune response

1 Aug 2005

Abstract excerpt

Complex signaling pathways regulate the innate immune system of insects, with NF-kappaB transcription factors playing a central role in the activation of antimicrobial peptides and other immune genes. Although numerous studies have characterized the immune responses of insects to pathogens, comparatively little is known about the counter-strategies pathogens have evolved to circumvent host defenses. Among the...

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PMID: 16061795
DOI: 10.1073/pnas.0505240102

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