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The evolution of regulated cell death pathways in animals and their evasion by pathogens

13 Dec 2021

Abstract excerpt

The coevolution of host-pathogen interactions underlies many human physiological traits associated with protection from or susceptibility to infections. Among the mechanisms that animals utilize to control infections are the regulated cell death pathways of pyroptosis, apoptosis, and necroptosis. Over the course of evolution these pathways have become intricate and complex, coevolving with microbes that infect...

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PMID: 34898294
DOI: 10.1152/physrev.00002.2021

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