Article
Validation of a method for localised microinjection of drugs into thalamic subregions in rats for epilepsy pharmacological studies.
Journal of neuroscience methods - 15 Aug 2005
Lohman Rink-Jan, Liu Lige, Morris Margaret, O'Brien Terence J
Abstract excerpt
OBJECTIVES: To validate a method for the chronic implantation of micro-cannulae to examine the effect of drug administration to two small brain regions critical to the control of generalised seizures, the reticular nucleus of the thalamus (Rt) and the ventrobasal thalamus (VB), in a genetically epileptic rat model. METHOD: Micro-cannulae guides (length 9 mm, 26G, i.d. 0.24 mm, o.d. 0.46 mm) were implanted...
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