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Article

Characterization of a novel temperature-sensitive allele of the CUL1/AXR6 subunit of SCF ubiquitin-ligases.

The Plant journal : for cell and molecular biology - 1 Aug 2005

Quint Marcel, Ito Hironori, Zhang Wenjing, Gray William M

Abstract excerpt

Selective protein degradation by the ubiquitin-proteasome pathway has emerged as a key regulatory mechanism in a wide variety of cellular processes. The selective components of this pathway are the E3 ubiquitin-ligases which act downstream of the ubiquitin-activating and -conjugating enzymes to identify specific substrates for ubiquitinylation. SCF-type ubiquitin-ligases are the most abundant class of E3 enzymes...

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Source

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Identifiers

PMID: 16045473
DOI: 10.1111/j.1365-313X.2005.02449.x
PMCID: PMC1363743

Genes

CUL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a novel temperature-sensitive allele of the CUL1/AXR6 subunit of SCF ubiquitin-ligases.PMID 16045473Read ↗

Arabidopsis AXR6 encodes CUL1 implicating SCF E3 ligases in auxin regulation of embryogenesis.Semantic proximity Read ↗

Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana.Semantic proximity Read ↗

A new temperature-insensitive allele of the Arabidopsis AXR6/CUL1 locus derived from a missense mutation in the C-terminal RBX1 binding region.Semantic proximity Read ↗

Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase.Semantic proximity Read ↗

The IAA1 protein is encoded by AXR5 and is a substrate of SCF(TIR1).Semantic proximity Read ↗

The AtRbx1 protein is part of plant SCF complexes, and its down-regulation causes severe growth and developmental defects.Semantic proximity Read ↗

A new CULLIN 1 mutant has altered responses to hormones and light in Arabidopsis.Semantic proximity Read ↗

Arabidopsis SGT1b is required for SCF(TIR1)-mediated auxin response.Semantic proximity Read ↗

Multiple ubiquitin ligase-mediated processes require COP9 signalosome and AXR1 function.Semantic proximity Read ↗

AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 is required for auxin response.Semantic proximity Read ↗

COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis.Semantic proximity Read ↗

Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins.Semantic proximity Read ↗

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