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Article

Evidence for macrophage‐mediated myelin disruption in an animal model for Charcot‐Marie‐Tooth neuropathy type 1A

22 Jul 2005

Abstract excerpt

Charcot-Marie-Tooth neuropathy type 1A (CMT 1 A) is the most common inherited neuropathy in humans and is mostly caused by a 1.5-Mb tandem duplication of chromosome 17 comprising the gene for the peripheral myelin protein 22-kDa (PMP 22). Although there are numerous studies on the functional role of PMP 22, the mechanisms of myelin degeneration under PMP 22-overexpression conditions have not yet been fully...

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PMID: 16041800
DOI: 10.1002/jnr.20601

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Evidence for macrophage‐mediated myelin disruption in an animal model for Charcot‐Marie‐Tooth neuropathy type 1APMID 16041800Read ↗

Attenuation of MCP-1/CCL2 expression ameliorates neuropathy in a mouse model for Charcot–Marie–Tooth 1XSemantic proximity Read ↗

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Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic miceSemantic proximity Read ↗

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