Cell-Free DNA in Serum and Plasma: Comparison of ELISA and Quantitative PCR

Abstract excerpt

Although circulating DNA has generally been referred to as cell-free DNA, it is likely that a significant proportion is bound to protein molecules, possibly as nucleosomes. This conclusion is supported by theory and by observations. Theoretically, circulating DNA is mostly released from degrading cells after cleavage by endonucleases that cut the chromatin into the basic nucleosomal elements (1)(2). Empirically,...

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