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Article

'O-Acyl isopeptide method' for the efficient preparation of amyloid beta peptide 1-42 mutants.

Bioorganic & medicinal chemistry - 15 Nov 2005

Sohma Youhei, Chiyomori Yousuke, Kimura Maiko, Fukao Fukue, Taniguchi Atsuhiko, Hayashi Yoshio, Kimura Tooru, Kiso Yoshiaki

Abstract excerpt

Novel water-soluble isopeptides of Abeta1-42 mutants, '26-O-acyl isoAbeta1-42 (26-AIAbeta42) mutants', which were efficiently converted to intact Abeta1-42 mutants with no byproduct formation under physiological conditions, were synthesized. These isopeptides provide a new system useful for investigating the biological function of Abeta1-42 mutants.

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Identifiers

PMID: 16040249
DOI: 10.1016/j.bmc.2005.06.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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