Article
Antineoplastic Agents. 545. Isolation and Structure of Turbostatins 1−4 from the Asian Marine Mollusk <i>Turbo stenogyrus</i> <sup>,1</sup>
14 Jun 2005
Abstract excerpt
The cancer cell line bioassay-guided separation of an extract from the marine mollusk Turbo stenogyrus led to the isolation of four new cerebrosides designated turbostatins 1-4 (1-4). The structure of each glycolipid was determined by interpreting results of a series of HR-APCI-MS and NMR (1D and 2D) spectral analyses. All four turbostatins exhibited significant (GI50 0.15-2.6 microg/mL) cancer cell growth...
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