Article
Symplostatin 3, a New Dolastatin 10 Analogue from the Marine Cyanobacterium <i>Symploca </i>sp. VP452
20 Dec 2001
Abstract excerpt
Symplostatin 3 (1), a new analogue of dolastatin 10 (2), has been isolated from a tumor selective extract of a Hawaiian variety of the marine cyanobacterium Symploca sp. VP452. Compound 1 differs from 2 only in the C-terminal unit; the dolaphenine unit is substituted by a 3-phenyllactic acid residue. Symplostatin 3 (1) possesses IC(50) values for in vitro cytotoxicity toward human tumor cell lines ranging from...
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