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Article

Functional replacement of Drosophila Btk29A with human Btk in male genital development and survival.

FEBS letters - 1 Aug 2005

Hamada Noriko, Bäckesjö Carl-Magnus, Smith C I Edvard, Yamamoto Daisuke

Abstract excerpt

Drosophila type 2 Btk29A reveals the highest homology to Btk among mammalian Tec kinases. In Btk29A(ficP) mutant males, the apodeme holding the penis split into two pieces. Human Btk rescued this phenotype in 39% of Btk29A(ficP) males, while the Drosophila transgenes did so in 90-100% of mutants. The Btk29A(ficP) mutation reduced adult longevity to 11% that of wild-type. This effect was counteracted by Drosophila...

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Identifiers

PMID: 16023106
DOI: 10.1016/j.febslet.2005.06.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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