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Article

Essential erbB family phosphorylation in osteosarcoma as a target for CI‐1033 inhibition

8 Jul 2005

Abstract excerpt

BACKGROUND: The role of erbB tyrosine kinases, especially Her-2, in osteosarcoma has engendered intense debate. Some investigators identified an association between low-level Her-2 expression, compared to none, and poor patient outcome. Others questioned the importance of apparent cytoplasmic expression of Her-2, since membranous overexpression is associated with poor outcome in carcinomas. We previously...

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PMID: 16007579
DOI: 10.1002/pbc.20454

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