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Mycelia from Antrodia camphorata in Submerged Culture Induce Apoptosis of Human Hepatoma HepG2 Cells Possibly through Regulation of Fas Pathway

4 Jun 2005

Abstract excerpt

The objective of this study was to investigate the antiproliferative effect and the mechanism of the methanol extracts of mycelia (MEM) form Antrodia camphorata in submerged culture toward HepG2 cells. The results showed that MEM-induced cell apoptosis involved up-regulation of Fas and down-regulation of Bcl-2, DR3, DR4, TNFRI, and TNFRII in HepG2 cells, while no changes on the levels of Bax, Bid, Bad, and Bak...

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PMID: 15998114
DOI: 10.1021/jf050329+

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