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Article

Systematically perturbed folding patterns of amyotrophic lateral sclerosis (ALS)-associated SOD1 mutants.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2005

Lindberg Mikael J, Byström Roberth, Boknäs Niklas, Andersen Peter M, Oliveberg Mikael

Abstract excerpt

Amyotrophic lateral sclerosis is a neurodegenerative syndrome associated with 114 mutations in the gene encoding the cytosolic homodimeric enzyme Cu/Zn superoxide dismutase (SOD). In this article, we report that amyotrophic lateral sclerosis-associated SOD mutations with distinctly different disease progression can be rationalized in terms of their folding patterns. The mutations are found to perturb the protein...

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Source

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Identifiers

PMID: 15987780
DOI: 10.1073/pnas.0501957102
PMCID: PMC1174986

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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