Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations

Abstract excerpt

Anti-endothelial-cell antibodies are associated with psychiatric manifestations in systemic lupus erythematosus (SLE). Our primary aim in this study was to seek and characterize molecules that behave as endothelial autoantigens in SLE patients with psychiatric manifestations. By screening a cDNA library from human umbilical artery endothelial cells with serum from an SLE patient with psychosis, we identified one...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Atherosclerosis and Cardiovascular Diseases
• Share to Systemic Lupus Erythematosus Research
• Share to T-cell and B-cell Immunology