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Article

GDF11 controls the timing of progenitor cell competence in developing retina.

Science (New York, N.Y.) - 24 Jun 2005

Kim Joon, Wu Hsiao-Huei, Lander Arthur D, Lyons Karen M, Matzuk Martin M, Calof Anne L

Abstract excerpt

The orderly generation of cell types in the developing retina is thought to be regulated by changes in the competence of multipotent progenitors. Here, we show that a secreted factor, growth and differentiation factor 11 (GDF11), controls the numbers of retinal ganglion cells (RGCs), as well as amacrine and photoreceptor cells, that form during development. GDF11 does not affect proliferation of progenitors-a...

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Source

Identifiers

PMID: 15976303
DOI: 10.1126/science.1110175

Genes

GDF11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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