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Article

Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1.

Molecular and cellular biology - 1 Jul 2005

Shetty Shashirekha, Graham Bonnie A, Brown Jennifer G, Hu Xiaojie, Vegh-Yarema Nicolette, Harding Gary, Paul James T, Gibson Spencer B

Abstract excerpt

The transcription factor nuclear factor kappaB (NF-kappaB) regulates the expression of both anti-apoptotic and proapoptotic genes. Death receptor 5 (DR5, TRAIL-R2) is a proapoptotic protein considered to be a potential target for cancer therapy, and its expression is mediated by NF-kappaB. The mechanism of NF-kappaB-induced DR5 expression is, however, unknown. Herein, we determined that etoposide-induced DR5...

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Identifiers

PMID: 15964798
DOI: 10.1128/MCB.25.13.5404-5416.2005
PMCID: PMC1156987

Genes

EGF
HDAC1

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