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Article

Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL‐R2 gene 1

2 Nov 2001

Abstract excerpt

The death receptor 5 (DR5) is a receptor for tumor necrosis factor-related apoptosis-inducing ligand and is able to induce apoptosis in various tumor cells. The expression of DR5 is up-regulated at the transcriptional level by p53, genotoxic stress and so on. To investigate the structure of the DR5 gene promoter, we screened and sequenced a genomic clone containing the 5'-flanking region of the DR5 gene. RNase...

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PMID: 11696376
DOI: 10.1016/s0014-5793(01)02947-7

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