Tumor suppressor and growth regulatory genes are overexpressed in severe early‐onset preeclampsia – an array study on case‐specific human preeclamptic placental tissue

Abstract excerpt

BACKGROUND: Preeclampsia is an important clinical condition with unknown etiology. We used DNA array technique to compare placental gene expression profile in severe early-onset preeclampsia from 25 to 27 gestational weeks with strictly non-affected placental samples from similar gestational weeks. METHOD: DNA arrays were validated by showing the up-regulation of several genes typical for preeclampsia such as...

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