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Article

Pathogenesis of severe acute respiratory syndrome.

Current opinion in immunology - 1 Aug 2005

Lau Yu Lung, Peiris J S Malik

Abstract excerpt

Severe acute respiratory syndrome (SARS) is a zoonotic infectious disease caused by a novel coronavirus (CoV). The tissue tropism of SARS-CoV includes not only the lung, but also the gastrointestinal tract, kidney and liver. Angiotensin-converting enzyme 2 (ACE2), the C-type lectin CD209L (also known L-SIGN), and DC-SIGN bind SARS-CoV, but ACE2 appears to be the key functional receptor for the virus. There is a...

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Identifiers

PMID: 15950449
DOI: 10.1016/j.coi.2005.05.009
PMCID: PMC7127490

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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