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Article

Endomitosis and polyploidization of myocardial cells in the periphery of human acute myocardial infarction

4 Apr 2005

Abstract excerpt

OBJECTIVE: Although the genetic program for reinitiating DNA synthesis exists in post-mitotic cardiomyocytes, and it was reported that in human acute myocardial infarction (AMI) a significant proportion of myocytes enter mitosis, the rule is that the lost tissue is replaced by a collagen scar. The purpose of this study was to search for the basis of this discordance in order to devise future strategies to induce...

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PMID: 15949475
DOI: 10.1016/j.cardiores.2005.02.017

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