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Article

High surface energy enhances cell response to titanium substrate microstructure.

Journal of biomedical materials research. Part A - 1 Jul 2005

Zhao G, Schwartz Z, Wieland M, Rupp F, Geis-Gerstorfer J, Cochran D L, Boyan B D

Abstract excerpt

Titanium (Ti) is used for implantable devices because of its biocompatible oxide surface layer. TiO2 surfaces that have a complex microtopography increase bone-to-implant contact and removal torque forces in vivo and induce osteoblast differentiation in vitro. Studies examining osteoblast response to controlled surface chemistries indicate that hydrophilic surfaces are osteogenic, but TiO2 surfaces produced until...

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Source

Identifiers

PMID: 15924300
DOI: 10.1002/jbm.a.30320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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