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Article

CCT chaperonin complex is required for the biogenesis of functional Plk1.

Molecular and cellular biology - 1 Jun 2005

Liu Xiaoqi, Lin Chin-Yo, Lei Ming, Yan Shi, Zhou Tianhua, Erikson Raymond L

Abstract excerpt

Experiments from several different organisms have demonstrated that polo-like kinases are involved in many aspects of mitosis and cytokinesis. Here, we provide evidence to show that Plk1 associates with chaperonin-containing TCP1 complex (CCT) both in vitro and in vivo. Silencing of CCT by use of RNA interference (RNAi) in mammalian cells inhibits cell proliferation, decreases cell viability, causes cell cycle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15923617
DOI: 10.1128/MCB.25.12.4993-5010.2005
PMCID: PMC1140568

Genes

TCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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CCT chaperonin complex is required for the biogenesis of functional Plk1.PMID 15923617Read ↗

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U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint.Semantic proximity Read ↗

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