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Article

Peroxisome proliferator-activated receptor-gamma2 P12A polymorphism and risk of coronary heart disease in US men and women.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2005

Pischon Tobias, Pai Jennifer K, Manson JoAnn E, Hu Frank B, Rexrode Kathryn M, Hunter David, Rimm Eric B

Abstract excerpt

OBJECTIVE: Activation of the peroxisome proliferator-activated receptor-gamma (PPARgamma) improves insulin sensitivity and exerts antiatherogenic effects. A common alanine for proline substitution at codon 12 in the PPARG2 gene is related to lower receptor activity. Studies suggest that the A12 a...

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PMID: 15920035
DOI: 10.1161/01.ATV.0000171993.78135.7e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15920035-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Peroxisome proliferator-activated receptor-gamma2 P12A polymorphism and risk of coronary heart disease in US men and women.PMID 15920035Read ↗

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