Article
Clinical variability in a Japanese hereditary lymphedema type I family with an FLT4 mutation.
Congenital anomalies - 1 Jun 2005
Mizuno Seiji, Yamada Yasukazu, Yamada Kenichiro, Nomura Noriko, Wakamatsu Nobuaki
Abstract excerpt
Hereditary lymphedema type I (Milroy disease) is a rare autosomal dominant disease resulting from mutations of FLT4 encoding the vascular endothelial growth factor receptor-3. Patients develop edema of the legs and feet, resulting in chronic swelling of the lower extremities from the neonatal period. Here we report a Japanese family with 10 affected members of five generations of hereditary lymphedema type I. We...
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