Article
Pheochromocytoma in von Hippel-Lindau disease and neurofibromatosis type 1.
Familial cancer - 1 Jan 2005
Opocher Giuseppe, Conton Pierantonio, Schiavi Francesca, Macino Beatrice, Mantero Franco
Abstract excerpt
Clinical and genetic understanding of chromaffin tumors has been greatly enhanced in the last few years. Although some pheochromocytoma genes may still be unknown, the role of RET, VHL, SDHB, SDHD and NF1 genes is unequivocal and phenotypes are also being better characterized. The loss of function of VHL and NF1 genes can lead to a variety of tumors including phechromocytoma and their mechanism of action is under...
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