Mycobacterium avium 104 deleted of the methyltransferase D gene by allelic replacement lacks serotype‐specific glycopeptidolipids and shows attenuated virulence in mice

Abstract excerpt

Mycobacterium avium is a major opportunistic pathogen of AIDS patients in the United States. The understanding of M. avium pathogenesis has been hampered by the inability to create gene knockouts by homologous recombination, an important mechanism for defining and characterizing virulence factors. In this study a functional methyltransferase D (mtfD) gene was deleted by allelic replacement in the M. avium strain...

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