Article
Loss of blood group A antigen expression in bladder cancer caused by allelic loss and/or methylation of the ABO gene.
Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2005
Chihara Yoshitomo, Sugano Kokichi, Kobayashi Ayumi, Kanai Yae, Yamamoto Hidenobu, Nakazono Masaaki, Fujimoto Hiroyuki, Kakizoe Tadao, Fujimoto Kiyohide, Hirohashi Setsuo, Hirao Yoshihiko
Abstract excerpt
Loss of ABO blood group antigen expression has been reported in transitional cell carcinoma (TCC) of the bladder. Synthesis of the ABO blood group antigen was genetically determined by allelic variants of the ABO gene assigned on 9q34.1. We analyzed loss of heterozygosity (LOH) and promoter hypermethylation of the ABO gene in TCC and compared them with alterations of A antigen expression in TCC, dysplasia and...
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