Article
Clinical and molecular events in patients with Machado-Joseph disease under lamotrigine therapy.
Acta neurologica Scandinavica - 1 Jun 2005
Liu C-S, Hsu H-M, Cheng W-L, Hsieh M
Abstract excerpt
OBJECTIVE: Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 is an autosomal dominant spinocerebellar degeneration, for which there is no effective treatment. PATIENTS AND METHODS: This study involved the clinical response of lamotrigine (LTG) on six MJD patients with early truncal ataxia and the effect of LTG on the alteration of ataxin-3 expression in the transformed MJD lymphoblastoid cells. RESULT:...
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