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Adeno-Associated Virus Pseudotype 5 Vector Improves Gene Transfer in Arthritic Joints

1 Apr 2005

Abstract excerpt

The potential for gene delivery to joints, using recombinant adeno-associated virus (rAAV) vectors for the treatment of rheumatoid arthritis (RA), has received much attention. Different serotypes have different virion shell proteins and, as a consequence, vary in their tropism for diverse tissues. The aim of this study was to compare the transduction efficiency of different AAV serotypes encoding murine secreted...

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PMID: 15871674
DOI: 10.1089/hum.2005.16.426

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