Article
Salt-sensitive blood pressure--an intermediate phenotype predisposing to diabetic nephropathy?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Oct 2005
Strojek Krzysztof, Nicod Jerome, Ferrari Paolo, Grzeszczak Wladyslaw, Gorska Juta, Dick Bernard, Frey Felix, Ritz Eberhard
Abstract excerpt
BACKGROUND: Family studies point to important genetic determinants of diabetic nephropathy (DN). Blood pressure (BP) is higher in offspring of patients with type 2 diabetes and DN, but the pathomechanisms involved have not been elucidated. METHODS: We examined the salt sensitivity of BP after 5 days equilibration on a low (20 mmol/day) vs high salt diet (220 mmol/day) in three matched groups of 15 subjects each:...
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