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Article

SNPs in the promoter region of the osteopontin gene as a marker predicting the efficacy of interferon-based therapies in patients with chronic hepatitis C.

Journal of gastroenterology - 1 Apr 2005

Naito Masashi, Matsui Atsushi, Inao Mie, Nagoshi Sumiko, Nagano Makoto, Ito Nobuko, Egashira Tohru, Hashimoto Michie, Mishiro Shunji, Mochida Satoshi, Fujiwara Kenji

Abstract excerpt

BACKGROUND: The T-helper (Th)1 immune reaction is essential for the eradication of hepatitis C virus (HCV) during interferon (IFN) therapy in patients with chronic hepatitis C. Osteopontin is a cytokine crucial for the initiation of the Th1 response. Recently, we identified four single-nucleotide polymorphisms (SNPs) in the promoter region of the osteopontin gene (OPN), at nucleotide (nt) -155, -443, -616, and...

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PMID: 15868370
DOI: 10.1007/s00535-005-1558-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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