Article
The selective epidermal growth factor receptor tyrosine kinase inhibitor PD153035 suppresses expression of prometastasis phenotypes in malignant pleural mesothelioma cells in vitro.
The Journal of thoracic and cardiovascular surgery - 1 May 2005
Cole George W, Alleva Annette M, Reddy Rishindra M, Maxhimer Justin B, Zuo JingTong, Schrump David S, Nguyen Dao M
Abstract excerpt
OBJECTIVE: Malignant pleural mesothelioma is notoriously refractory to aggressive multimodality therapy. Epidermal growth factor receptor expression has been observed on malignant pleural mesothelioma cells. Epidermal growth factor receptor-mediated signaling promotes tumorigenesis and metastasis of cancer cells. The purpose of this study is to evaluate the ability of the epidermal growth factor receptor tyrosine...
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