Article
Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice.
Journal of lipid research - 1 Jul 2005
Wu Dongfang, Yang Hong, Xiang Wei, Zhou Lichun, Shi Mingjian, Julies George, Laplante Janice M, Ballard Billy R, Guo Zhongmao
Abstract excerpt
Individuals with a heterozygous mutation at the ataxia-telangiectasia mutated gene (ATM) have been reported to be predisposed to ischemic heart disease. This report examined for the first time the effect of a heterozygous ATM mutation (ATM(+)(/-)) on plasma lipid levels and atherosclerosis intensity using ATM(+/-), ATM(+)(/+) (wild type), ATM(+)(/+)/LDLR(-)(/-) (low density lipoprotein receptor knockout),...
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