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Article

The status of EGFR-associated genes could predict the outcome and tumor response of chemo-refractory metastatic colorectal patients using cetuximab and chemotherapy.

Journal of surgical oncology - 1 Nov 2011

Lin Jen-Kou, Lin An-Jen, Lin Chun-Chi, Lan Yuan-Tzu, Yang Shung-Haur, Li Anna Fen-Yau, Chang Shih-Ching

Abstract excerpt

PURPOSE: This study was designed to analyze the impacts of status of EGFR-associated genes on the outcome of chemo-refractory mCRC patients using cetuximab. MATERIALS AND METHODS: We collected samples from 42 metastatic CRC patients refractory to FOLFOX or FOLFIRI. Mutation profiles of KRAS, BRAF, PTEN, and PI3KCA and the copy numbers of EGFR and PTEN were analyzed. Overall survival and tumor response between...

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Source

Identifiers

PMID: 21671463
DOI: 10.1002/jso.21993

Genes

EGFR
KRAS
PTEN
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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