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Article

Long CGG-repeat tracts are toxic to human cells: implications for carriers of Fragile X premutation alleles.

FEBS letters - 9 May 2005

Handa Vaishali, Goldwater Deena, Stiles David, Cam Margaret, Poy George, Kumari Daman, Usdin Karen

Abstract excerpt

People with 59-200 CGG.CCG-repeats in the 5' UTR of one of their FMR1 genes are at risk for Fragile X tremor and ataxia syndrome. Females are also at risk for premature ovarian failure. These symptoms are thought to be due to the presence of the repeats at the DNA and/or RNA level. We show here that long transcribed but untranslated CGG-repeat tracts are toxic to human cells and alter the expression of a wide...

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Source

Identifiers

PMID: 15862312
DOI: 10.1016/j.febslet.2005.04.004

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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